Creatinine is removed from blood into urine by kidneys. When kidneys work well, the creatinine level in blood will keep in a certain range. The normal range of serum creatinine can be 0.6-1.5 mg/dl or 60-120umol/L (The range may change due to different standard or different machines in different countries.). When there is a high creatinine level in blood, it can indicate there is kidney disease or kidney damage on the person. Therefore, to check if the creatinine is high in blood has a significant meaning in diagnosing kidney disease.
High serum creatinine level is one of the most annoying problems among people with kidney disease and long-term it will cause damages to our other organs. Well then, how to control the high creatinine level?
What Causes High Serum Creatinine Level in Diabetics.
For diabetics, kidney disease is a result of glomerular capillary damage caused by high blood sugar. Other risk factors for diabetic kidney disease(diabetic nephropathy) include high blood pressure, smoking and heredity susceptibility. Due to deposition of exellular matrix and thickening mesangial basement membrane, more and more renal intrinsic cells are damaged, causing continuous kidney function decline.
Throughout the deteriorating process, increasing protein in urine is a typical symptom, which is usually accompanied by swelling(edema). What comes along kidneys' insufficiency to filtrate blood is the increasing serum creatinine, blood urea nitrogen and accumulation of other wastes products. Overall metabolism turned into disorder and multiple complications appear, including:
1. Water metabolism disorder, causing symptoms such as polyuria, nocturia, thirst, mucosal dryness, fatigue, etc; or systemic edema, high blood pressure, pulmonary edema and heart failure.
2. Erythrocyte imbalance
Normal kidneys are effective in regulating erythrocyte balance. When kidneys are severely impaired, erythrocyte imbalance will present, causing hyperkalemia or hypokalemia, hypernatremia or hyponatremia.
3. Metabolic acidosis, causing symptoms such as deep breathing, anorexia, abdominal pain, nausea, vomiting, weakness, headache, irritability or even coma.
4. Endocrine dysfunction, such as thyroid dysfunction, sexual dysfunction, growth retardation and so on.
5. Metabolic disorders, including carbohydrate metabolism disorder, lipid metabolic disorder, protein and amino acid metabolic disorder, etc.
The above symptoms are caused by severe kidney injury. For diabetics, there can be accompanied complications caused by longstanding diabetes, such as diabetic retinopathy, cardiovascular diseases, diabetic peripheral lesions, diabetic neuropathy and so on. Those combined situations can be life-threatening to diabetics.